CovidSeniorV1, Main, Exploration, bibRecord, 000648

Distinct Early Serological Signatures Track with SARS-CoV-2 Survival.

Identifieur interne : 000648 ( Main/Exploration ); précédent : 000647; suivant : 000649

Distinct Early Serological Signatures Track with SARS-CoV-2 Survival.

Auteurs : Caroline Atyeo [États-Unis] ; Stephanie Fischinger [Allemagne] ; Tomer Zohar [États-Unis] ; Matthew D. Slein [États-Unis] ; John Burke [États-Unis] ; Carolin Loos [États-Unis] ; Denise J. Mcculloch [États-Unis] ; Kira L. Newman [États-Unis] ; Caitlin Wolf [États-Unis] ; Jingyou Yu [États-Unis] ; Kiel Shuey [États-Unis] ; Jared Feldman [États-Unis] ; Blake Marie Hauser [États-Unis] ; Tim Caradonna [États-Unis] ; Aaron G. Schmidt [États-Unis] ; Todd J. Suscovich [États-Unis] ; Caitlyn Linde [États-Unis] ; Yongfei Cai [États-Unis] ; Dan Barouch [États-Unis] ; Edward T. Ryan [États-Unis] ; Richelle C. Charles [États-Unis] ; Douglas Lauffenburger [États-Unis] ; Helen Chu [États-Unis] ; Galit Alter [États-Unis]

Source :

Immunity [ 1097-4180 ] ; 2020.

RBID : pubmed:32783920

Descripteurs français

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Antibodies, Viral (blood), Betacoronavirus (immunology), Coronavirus Infections (blood), Coronavirus Infections (immunology), Coronavirus Infections (mortality), Female (MeSH), Humans (MeSH), Immunity, Humoral (immunology), Immunoglobulin G (blood), Male (MeSH), Middle Aged (MeSH), Nucleocapsid Proteins (immunology), Pandemics (MeSH), Pneumonia, Viral (blood), Pneumonia, Viral (immunology), Pneumonia, Viral (mortality), Spike Glycoprotein, Coronavirus (immunology).
MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G.
- blood : Coronavirus Infections, Pneumonia, Viral.
- immunology : Betacoronavirus, Coronavirus Infections, Immunity, Humoral, Nucleocapsid Proteins, Pneumonia, Viral, Spike Glycoprotein, Coronavirus.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Pandemics.

Abstract

As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some individuals recover from infection, whereas others rapidly progress and die. Although the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point to immunological mechanisms of protection. Here, we profiled SARS-CoV-2-specific humoral responses in a cohort of 22 hospitalized individuals. Despite inter-individual heterogeneity, distinct antibody signatures resolved individuals with different outcomes. Although no differences in SARS-CoV-2-specific IgG levels were observed, spike-specific humoral responses were enriched among convalescent individuals, whereas functional antibody responses to the nucleocapsid were elevated in deceased individuals. Furthermore, this enriched immunodominant spike-specific antibody profile in convalescents was confirmed in a larger validation cohort. These results demonstrate that early antigen-specific and qualitative features of SARS-CoV-2-specific antibodies point to differences in disease trajectory, highlighting the potential importance of functional antigen-specific humoral immunity to guide patient care and vaccine development.

DOI: 10.1016/j.immuni.2020.07.020
PubMed: 32783920
PubMed Central: PMC7392190

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Newman, Kira L" sort="Newman, Kira L" uniqKey="Newman K" first="Kira L" last="Newman">Kira L. Newman</name>
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<author><name sortKey="Wolf, Caitlin" sort="Wolf, Caitlin" uniqKey="Wolf C" first="Caitlin" last="Wolf">Caitlin Wolf</name>
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<author><name sortKey="Yu, Jingyou" sort="Yu, Jingyou" uniqKey="Yu J" first="Jingyou" last="Yu">Jingyou Yu</name>
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<author><name sortKey="Shuey, Kiel" sort="Shuey, Kiel" uniqKey="Shuey K" first="Kiel" last="Shuey">Kiel Shuey</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Caradonna, Tim" sort="Caradonna, Tim" uniqKey="Caradonna T" first="Tim" last="Caradonna">Tim Caradonna</name>
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<author><name sortKey="Schmidt, Aaron G" sort="Schmidt, Aaron G" uniqKey="Schmidt A" first="Aaron G" last="Schmidt">Aaron G. Schmidt</name>
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<author><name sortKey="Suscovich, Todd J" sort="Suscovich, Todd J" uniqKey="Suscovich T" first="Todd J" last="Suscovich">Todd J. Suscovich</name>
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<author><name sortKey="Linde, Caitlyn" sort="Linde, Caitlyn" uniqKey="Linde C" first="Caitlyn" last="Linde">Caitlyn Linde</name>
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<author><name sortKey="Cai, Yongfei" sort="Cai, Yongfei" uniqKey="Cai Y" first="Yongfei" last="Cai">Yongfei Cai</name>
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<author><name sortKey="Barouch, Dan" sort="Barouch, Dan" uniqKey="Barouch D" first="Dan" last="Barouch">Dan Barouch</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215</wicri:regionArea>
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</placeName>
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<author><name sortKey="Ryan, Edward T" sort="Ryan, Edward T" uniqKey="Ryan E" first="Edward T" last="Ryan">Edward T. Ryan</name>
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<author><name sortKey="Charles, Richelle C" sort="Charles, Richelle C" uniqKey="Charles R" first="Richelle C" last="Charles">Richelle C. Charles</name>
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<wicri:regionArea>Infectious Disease Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
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<author><name sortKey="Lauffenburger, Douglas" sort="Lauffenburger, Douglas" uniqKey="Lauffenburger D" first="Douglas" last="Lauffenburger">Douglas Lauffenburger</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
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<author><name sortKey="Chu, Helen" sort="Chu, Helen" uniqKey="Chu H" first="Helen" last="Chu">Helen Chu</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: helenchu@uw.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
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<author><name sortKey="Alter, Galit" sort="Alter, Galit" uniqKey="Alter G" first="Galit" last="Alter">Galit Alter</name>
<affiliation wicri:level="2"><nlm:affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA. Electronic address: galter@partners.org.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Distinct Early Serological Signatures Track with SARS-CoV-2 Survival.</title>
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<wicri:regionArea>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; PhD Program in Virology, Division of Medical Sciences, Harvard University, Boston, MA</wicri:regionArea>
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<settlement type="city">Cambridge (Massachusetts)</settlement>
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<author><name sortKey="Fischinger, Stephanie" sort="Fischinger, Stephanie" uniqKey="Fischinger S" first="Stephanie" last="Fischinger">Stephanie Fischinger</name>
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<country xml:lang="fr">Allemagne</country>
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<wicri:noRegion>Essen</wicri:noRegion>
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<wicri:noRegion>Essen</wicri:noRegion>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
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<author><name sortKey="Slein, Matthew D" sort="Slein, Matthew D" uniqKey="Slein M" first="Matthew D" last="Slein">Matthew D. Slein</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
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<author><name sortKey="Burke, John" sort="Burke, John" uniqKey="Burke J" first="John" last="Burke">John Burke</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Loos, Carolin" sort="Loos, Carolin" uniqKey="Loos C" first="Carolin" last="Loos">Carolin Loos</name>
<affiliation wicri:level="2"><nlm:affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
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<author><name sortKey="Mcculloch, Denise J" sort="Mcculloch, Denise J" uniqKey="Mcculloch D" first="Denise J" last="Mcculloch">Denise J. Mcculloch</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Newman, Kira L" sort="Newman, Kira L" uniqKey="Newman K" first="Kira L" last="Newman">Kira L. Newman</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Wolf, Caitlin" sort="Wolf, Caitlin" uniqKey="Wolf C" first="Caitlin" last="Wolf">Caitlin Wolf</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Yu, Jingyou" sort="Yu, Jingyou" uniqKey="Yu J" first="Jingyou" last="Yu">Jingyou Yu</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shuey, Kiel" sort="Shuey, Kiel" uniqKey="Shuey K" first="Kiel" last="Shuey">Kiel Shuey</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Feldman, Jared" sort="Feldman, Jared" uniqKey="Feldman J" first="Jared" last="Feldman">Jared Feldman</name>
<affiliation wicri:level="2"><nlm:affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauser, Blake Marie" sort="Hauser, Blake Marie" uniqKey="Hauser B" first="Blake Marie" last="Hauser">Blake Marie Hauser</name>
<affiliation wicri:level="2"><nlm:affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Caradonna, Tim" sort="Caradonna, Tim" uniqKey="Caradonna T" first="Tim" last="Caradonna">Tim Caradonna</name>
<affiliation wicri:level="2"><nlm:affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmidt, Aaron G" sort="Schmidt, Aaron G" uniqKey="Schmidt A" first="Aaron G" last="Schmidt">Aaron G. Schmidt</name>
<affiliation wicri:level="2"><nlm:affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Suscovich, Todd J" sort="Suscovich, Todd J" uniqKey="Suscovich T" first="Todd J" last="Suscovich">Todd J. Suscovich</name>
<affiliation wicri:level="2"><nlm:affiliation>SeromYx Systems, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>SeromYx Systems, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Linde, Caitlyn" sort="Linde, Caitlyn" uniqKey="Linde C" first="Caitlyn" last="Linde">Caitlyn Linde</name>
<affiliation wicri:level="2"><nlm:affiliation>SeromYx Systems, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>SeromYx Systems, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cai, Yongfei" sort="Cai, Yongfei" uniqKey="Cai Y" first="Yongfei" last="Cai">Yongfei Cai</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Molecular Medicine, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Molecular Medicine, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barouch, Dan" sort="Barouch, Dan" uniqKey="Barouch D" first="Dan" last="Barouch">Dan Barouch</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ryan, Edward T" sort="Ryan, Edward T" uniqKey="Ryan E" first="Edward T" last="Ryan">Edward T. Ryan</name>
<affiliation wicri:level="2"><nlm:affiliation>Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Infectious Disease Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Charles, Richelle C" sort="Charles, Richelle C" uniqKey="Charles R" first="Richelle C" last="Charles">Richelle C. Charles</name>
<affiliation wicri:level="2"><nlm:affiliation>Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Infectious Disease Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lauffenburger, Douglas" sort="Lauffenburger, Douglas" uniqKey="Lauffenburger D" first="Douglas" last="Lauffenburger">Douglas Lauffenburger</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chu, Helen" sort="Chu, Helen" uniqKey="Chu H" first="Helen" last="Chu">Helen Chu</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: helenchu@uw.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Alter, Galit" sort="Alter, Galit" uniqKey="Alter G" first="Galit" last="Alter">Galit Alter</name>
<affiliation wicri:level="2"><nlm:affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA. Electronic address: galter@partners.org.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Immunity</title>
<idno type="eISSN">1097-4180</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Antibodies, Viral (blood)</term>
<term>Betacoronavirus (immunology)</term>
<term>Coronavirus Infections (blood)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunity, Humoral (immunology)</term>
<term>Immunoglobulin G (blood)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Nucleocapsid Proteins (immunology)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (blood)</term>
<term>Pneumonia, Viral (immunology)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Spike Glycoprotein, Coronavirus (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Anticorps antiviraux (sang)</term>
<term>Betacoronavirus (immunologie)</term>
<term>Femelle (MeSH)</term>
<term>Glycoprotéine de spicule des coronavirus (immunologie)</term>
<term>Humains (MeSH)</term>
<term>Immunité humorale (immunologie)</term>
<term>Immunoglobuline G (sang)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Infections à coronavirus (sang)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (immunologie)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (sang)</term>
<term>Protéines nucléocapside (immunologie)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
<term>Immunoglobulin G</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Betacoronavirus</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Immunité humorale</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Protéines nucléocapside</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Betacoronavirus</term>
<term>Coronavirus Infections</term>
<term>Immunity, Humoral</term>
<term>Nucleocapsid Proteins</term>
<term>Pneumonia, Viral</term>
<term>Spike Glycoprotein, Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Immunoglobuline G</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
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<front><div type="abstract" xml:lang="en">As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some individuals recover from infection, whereas others rapidly progress and die. Although the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point to immunological mechanisms of protection. Here, we profiled SARS-CoV-2-specific humoral responses in a cohort of 22 hospitalized individuals. Despite inter-individual heterogeneity, distinct antibody signatures resolved individuals with different outcomes. Although no differences in SARS-CoV-2-specific IgG levels were observed, spike-specific humoral responses were enriched among convalescent individuals, whereas functional antibody responses to the nucleocapsid were elevated in deceased individuals. Furthermore, this enriched immunodominant spike-specific antibody profile in convalescents was confirmed in a larger validation cohort. These results demonstrate that early antigen-specific and qualitative features of SARS-CoV-2-specific antibodies point to differences in disease trajectory, highlighting the potential importance of functional antigen-specific humoral immunity to guide patient care and vaccine development.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32783920</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-4180</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>53</Volume>
<Issue>3</Issue>
<PubDate><Year>2020</Year>
<Month>09</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Immunity</Title>
<ISOAbbreviation>Immunity</ISOAbbreviation>
</Journal>
<ArticleTitle>Distinct Early Serological Signatures Track with SARS-CoV-2 Survival.</ArticleTitle>
<Pagination><MedlinePgn>524-532.e4</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S1074-7613(20)30327-7</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.immuni.2020.07.020</ELocationID>
<Abstract><AbstractText>As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some individuals recover from infection, whereas others rapidly progress and die. Although the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point to immunological mechanisms of protection. Here, we profiled SARS-CoV-2-specific humoral responses in a cohort of 22 hospitalized individuals. Despite inter-individual heterogeneity, distinct antibody signatures resolved individuals with different outcomes. Although no differences in SARS-CoV-2-specific IgG levels were observed, spike-specific humoral responses were enriched among convalescent individuals, whereas functional antibody responses to the nucleocapsid were elevated in deceased individuals. Furthermore, this enriched immunodominant spike-specific antibody profile in convalescents was confirmed in a larger validation cohort. These results demonstrate that early antigen-specific and qualitative features of SARS-CoV-2-specific antibodies point to differences in disease trajectory, highlighting the potential importance of functional antigen-specific humoral immunity to guide patient care and vaccine development.</AbstractText>
<CopyrightInformation>Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Atyeo</LastName>
<ForeName>Caroline</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; PhD Program in Virology, Division of Medical Sciences, Harvard University, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fischinger</LastName>
<ForeName>Stephanie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; PhD Program in Immunology and Virology, University of Duisburg-Essen, Essen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zohar</LastName>
<ForeName>Tomer</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Slein</LastName>
<ForeName>Matthew D</ForeName>
<Initials>MD</Initials>
<AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Burke</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Loos</LastName>
<ForeName>Carolin</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McCulloch</LastName>
<ForeName>Denise J</ForeName>
<Initials>DJ</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Washington, Seattle, WA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Newman</LastName>
<ForeName>Kira L</ForeName>
<Initials>KL</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Washington, Seattle, WA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wolf</LastName>
<ForeName>Caitlin</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Washington, Seattle, WA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Jingyou</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shuey</LastName>
<ForeName>Kiel</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Washington, Seattle, WA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feldman</LastName>
<ForeName>Jared</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hauser</LastName>
<ForeName>Blake Marie</ForeName>
<Initials>BM</Initials>
<AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Caradonna</LastName>
<ForeName>Tim</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schmidt</LastName>
<ForeName>Aaron G</ForeName>
<Initials>AG</Initials>
<AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Suscovich</LastName>
<ForeName>Todd J</ForeName>
<Initials>TJ</Initials>
<AffiliationInfo><Affiliation>SeromYx Systems, Cambridge, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Linde</LastName>
<ForeName>Caitlyn</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>SeromYx Systems, Cambridge, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cai</LastName>
<ForeName>Yongfei</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Division of Molecular Medicine, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barouch</LastName>
<ForeName>Dan</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ryan</LastName>
<ForeName>Edward T</ForeName>
<Initials>ET</Initials>
<AffiliationInfo><Affiliation>Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Charles</LastName>
<ForeName>Richelle C</ForeName>
<Initials>RC</Initials>
<AffiliationInfo><Affiliation>Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lauffenburger</LastName>
<ForeName>Douglas</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chu</LastName>
<ForeName>Helen</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: helenchu@uw.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alter</LastName>
<ForeName>Galit</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA. Electronic address: galter@partners.org.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>U01 CK000490</GrantID>
<Acronym>CK</Acronym>
<Agency>NCEZID CDC HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U01CK000490</GrantID>
<Acronym>ACL</Acronym>
<Agency>ACL HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U19 AI135995</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>07</Month>
<Day>30</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Immunity</MedlineTA>
<NlmUniqueID>9432918</NlmUniqueID>
<ISSNLinking>1074-7613</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019590">Nucleocapsid Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C099602">nucleocapsid protein, Coronavirus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C000657845">spike protein, SARS-CoV-2</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056724" MajorTopicYN="N">Immunity, Humoral</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019590" MajorTopicYN="N">Nucleocapsid Proteins</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19 patients</Keyword>
<Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="Y">SARS-CoV-2-specific antibody</Keyword>
<Keyword MajorTopicYN="Y">functional antibody</Keyword>
</KeywordList>
<CoiStatement>Declaration of Interests G.A. is a founder of SeromYx Systems.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>05</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>06</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>07</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>8</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>9</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>8</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32783920</ArticleId>
<ArticleId IdType="pii">S1074-7613(20)30327-7</ArticleId>
<ArticleId IdType="doi">10.1016/j.immuni.2020.07.020</ArticleId>
<ArticleId IdType="pmc">PMC7392190</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
<li>Washington (État)</li>
</region>
<settlement><li>Cambridge (Massachusetts)</li>
<li>Seattle</li>
</settlement>
<orgName><li>Université Harvard</li>
<li>Université de Washington</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Atyeo, Caroline" sort="Atyeo, Caroline" uniqKey="Atyeo C" first="Caroline" last="Atyeo">Caroline Atyeo</name>
</region>
<name sortKey="Alter, Galit" sort="Alter, Galit" uniqKey="Alter G" first="Galit" last="Alter">Galit Alter</name>
<name sortKey="Barouch, Dan" sort="Barouch, Dan" uniqKey="Barouch D" first="Dan" last="Barouch">Dan Barouch</name>
<name sortKey="Burke, John" sort="Burke, John" uniqKey="Burke J" first="John" last="Burke">John Burke</name>
<name sortKey="Cai, Yongfei" sort="Cai, Yongfei" uniqKey="Cai Y" first="Yongfei" last="Cai">Yongfei Cai</name>
<name sortKey="Caradonna, Tim" sort="Caradonna, Tim" uniqKey="Caradonna T" first="Tim" last="Caradonna">Tim Caradonna</name>
<name sortKey="Charles, Richelle C" sort="Charles, Richelle C" uniqKey="Charles R" first="Richelle C" last="Charles">Richelle C. Charles</name>
<name sortKey="Chu, Helen" sort="Chu, Helen" uniqKey="Chu H" first="Helen" last="Chu">Helen Chu</name>
<name sortKey="Feldman, Jared" sort="Feldman, Jared" uniqKey="Feldman J" first="Jared" last="Feldman">Jared Feldman</name>
<name sortKey="Hauser, Blake Marie" sort="Hauser, Blake Marie" uniqKey="Hauser B" first="Blake Marie" last="Hauser">Blake Marie Hauser</name>
<name sortKey="Lauffenburger, Douglas" sort="Lauffenburger, Douglas" uniqKey="Lauffenburger D" first="Douglas" last="Lauffenburger">Douglas Lauffenburger</name>
<name sortKey="Linde, Caitlyn" sort="Linde, Caitlyn" uniqKey="Linde C" first="Caitlyn" last="Linde">Caitlyn Linde</name>
<name sortKey="Loos, Carolin" sort="Loos, Carolin" uniqKey="Loos C" first="Carolin" last="Loos">Carolin Loos</name>
<name sortKey="Mcculloch, Denise J" sort="Mcculloch, Denise J" uniqKey="Mcculloch D" first="Denise J" last="Mcculloch">Denise J. Mcculloch</name>
<name sortKey="Newman, Kira L" sort="Newman, Kira L" uniqKey="Newman K" first="Kira L" last="Newman">Kira L. Newman</name>
<name sortKey="Ryan, Edward T" sort="Ryan, Edward T" uniqKey="Ryan E" first="Edward T" last="Ryan">Edward T. Ryan</name>
<name sortKey="Schmidt, Aaron G" sort="Schmidt, Aaron G" uniqKey="Schmidt A" first="Aaron G" last="Schmidt">Aaron G. Schmidt</name>
<name sortKey="Shuey, Kiel" sort="Shuey, Kiel" uniqKey="Shuey K" first="Kiel" last="Shuey">Kiel Shuey</name>
<name sortKey="Slein, Matthew D" sort="Slein, Matthew D" uniqKey="Slein M" first="Matthew D" last="Slein">Matthew D. Slein</name>
<name sortKey="Suscovich, Todd J" sort="Suscovich, Todd J" uniqKey="Suscovich T" first="Todd J" last="Suscovich">Todd J. Suscovich</name>
<name sortKey="Wolf, Caitlin" sort="Wolf, Caitlin" uniqKey="Wolf C" first="Caitlin" last="Wolf">Caitlin Wolf</name>
<name sortKey="Yu, Jingyou" sort="Yu, Jingyou" uniqKey="Yu J" first="Jingyou" last="Yu">Jingyou Yu</name>
<name sortKey="Zohar, Tomer" sort="Zohar, Tomer" uniqKey="Zohar T" first="Tomer" last="Zohar">Tomer Zohar</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Fischinger, Stephanie" sort="Fischinger, Stephanie" uniqKey="Fischinger S" first="Stephanie" last="Fischinger">Stephanie Fischinger</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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   |wiki=    Sante
   |area=    CovidSeniorV1
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   |clé=     pubmed:32783920
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	Serveur d'exploration sur la COVID chez les séniors
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la COVID chez les séniors

Distinct Early Serological Signatures Track with SARS-CoV-2 Survival.

Distinct Early Serological Signatures Track with SARS-CoV-2 Survival.

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